Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events
Merkel cell carcinoma is a rare cutaneous neuroendocrine carcinoma with a high rate of regional and distant metastasis and mortality. Here, we report a novel case of Merkel cell carcinoma which presented as a primary lesion to the left cheek with regional lymph node involvement and was treated with...
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Veröffentlicht in: | Case reports in dermatological medicine 2020-09, Vol.2020 (2020), p.1-7 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Merkel cell carcinoma is a rare cutaneous neuroendocrine carcinoma with a high rate of regional and distant metastasis and mortality. Here, we report a novel case of Merkel cell carcinoma which presented as a primary lesion to the left cheek with regional lymph node involvement and was treated with pembrolizumab and radiation. Widely metastatic disease eventually revealed on autopsy clinically mimicked immune-related organ insult leading to management with immunosuppressants. The patient also had a biopsy-confirmed immune-related cutaneous adverse event during admission. The case highlights a rare circumstance in which disease progression masqueraded as multiple immune-related end-organ adverse events. Contribution of on-target anti-PD-1 toxicity remains a possibility. |
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ISSN: | 2090-6463 2090-6471 |
DOI: | 10.1155/2020/8890845 |