From Lab-on-chip to Lab-in-App: Challenges towards silicon photonic biosensors product developments

This work presents and evaluates different approaches of integrated optical sensors based on photonic integrated circuit (PIC) technologies for refractive index sensing. Bottlenecks in the fabrication flow towards an applicable system are discussed that hinder a cost-effective mass-production for disposable sensor chips. As sensor device, a waveguide coupled micro-ring based approach is chosen which is manufactured in an 8” wafer level process. We will show that the co-integration with a reproducible, scalable and low-cost microfluidic interface is the main challenge which needs to be overcome for future application of silicon technology based PIC sensor chips. •Si photonic technology with integrated microfluidic channel.•Co-integration of electronic, photonic and bio environment.•Proof of concept for interchangeable sensor chip for future point-of-care diagnostics.