Progress of CD8+CD25+regulatory T cells in diseases

CD8+CD25+Treg can inhibit immune response and induce immune tolerance. This article reviews the changes and underlying mechanisms of CD8+CD25+Treg in pathogenesis of malignant tumors, autoimmune diseases and other common diseases such as asthma, allergic diseases, type 2 diabetes, and pre-eclampsia....

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Veröffentlicht in:Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics 2022-12, Vol.42 (12), p.1939-1944
1. Verfasser: WEN Li-na, CHEN Li, DUAN Rui, LI Fang
Format: Artikel
Sprache:chi
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Zusammenfassung:CD8+CD25+Treg can inhibit immune response and induce immune tolerance. This article reviews the changes and underlying mechanisms of CD8+CD25+Treg in pathogenesis of malignant tumors, autoimmune diseases and other common diseases such as asthma, allergic diseases, type 2 diabetes, and pre-eclampsia. The changes of CD8+CD25+Treg in different diseases are inconsistent, cell counting increased in malignant diseases but decreased in autoimmune diseases. Further understanding of CD8+CD25+Treg would supporte a basis for the prevention, treatment and improving prognosis of these diseases.
ISSN:1001-6325
DOI:10.16352/j.issn.1001-6325.2022.12.1939