Bioassay-Guided Isolation of Antiproliferative Compounds from Limbarda crithmoides (L.) Dumort

Bioassay-Guided Isolation of Antiproliferative Compounds from Limbarda crithmoides (L.) Dumort

(L.) Dumort (Asteraceae) -hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate ( ) and 1...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2020-04, Vol.25 (8), p.1893
Hauptverfasser: Adorisio, Sabrina, Giamperi, Laura, Bucchini, Anahi Elena Ada, Delfino, Domenico Vittorio, Marcotullio, Maria Carla
Format: Artikel
Sprache:eng
Schlagworte:
Acute myeloid leukemia
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Antioxidants
antiproliferative activity
Antiproliferatives
Apoptosis
Asteraceae
Asteraceae - chemistry
Bioassays
Biological Assay
Cell cycle
Cell Cycle - drug effects
Cell Line, Tumor
Cell proliferation
Cell Survival
Cytotoxicity
Experiments
Humans
Inula crithmoides
Leukemia
Limbarda crithmoides
Magnetic Resonance Spectroscopy
Metabolites
Molecular Structure
NMR
NMR spectroscopy
Nuclear magnetic resonance
OCI-AML3
Oils & fats
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Thymol
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Zusammenfassung:(L.) Dumort (Asteraceae) -hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate ( ) and 10-acetoxy-9-chloro-8,9-dehydrothymol ( ), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-dependent inhibition of cell proliferation.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25081893