An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2-Propynol Benzyl Azides and Diarylphosphine Oxides

An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2-Propynol Benzyl Azides and Diarylphosphine Oxides

An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf) -catalyzed cascade cyclization of easily prepared ortho-propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and tole...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2019-09, Vol.24 (19), p.3526
Hauptverfasser: Yang, Tao, Song, Xian-Rong, Yang, Ruchun, Ding, Haixin, Bai, Jiang, Xiao, Qiang
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Antifungal agents
azides
Azides - chemistry
cascade cyclization
Catalysis
Chromatography
Communication
Cyclization
Isoindoles - chemistry
Molecular Structure
Oxides
phosphorylated isoindolines
Phosphorylation
Propanols - chemistry
propargylic alcohols
Triazoles
Triazoles - chemistry
Zinc
Zinc - chemistry
zn-catalyzed
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Zusammenfassung:An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf) -catalyzed cascade cyclization of easily prepared ortho-propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and tolerated various propargylic alcohol substrates.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24193526