All for one: Collaboration between dermatologist, radiation oncologist and radiologist in the clinical management of “difficult to treat” non melanoma skin cancer

•Multidisciplinary Approach: The article emphasizes the importance of a multidisciplinary approach in managing difficult-to-treat non-melanoma skin cancers (NMSCs), particularly those referred for radiotherapy (RT).•Integration of Dermoscopy and HFUS: Dermoscopy and high-frequency ultrasound (HFUS) are highlighted as essential diagnostic tools that complement clinical evaluations and assist in treatment planning for NMSCs.•Treatment Optimization: The article presents three challenging cases, demonstrating how the integration of dermoscopy and HFUS contributes to treatment optimization, particularly in cases of recurrence or complex lesions. This series introduces the clinical management of difficult-to-treat non-melanoma skin cancers (NMSCs) through a multidisciplinary approach, emphasizing the integration of dermoscopy and Ultra high-frequency ultrasound (UHFUS) for accurate diagnosis and treatment planning, particularly in cases referred for radiotherapy (RT). Dermoscopy aids in diagnosing both pigmented and non-pigmented skin lesions, guiding treatment margins and reducing the benign-to-malignant biopsy ratio. UHFUS provides valuable insights into tumor size, depth, and vascularity, complementing clinical evaluations and assisting in RT planning. Three challenging cases are presented, highlighting the pivotal role of dermoscopy and UHFUS in decision-making and treatment optimization. Collaboration between dermatologists, radiation oncologists, and radiologists enhances diagnostic accuracy, tailoring treatment plans to individual patient needs and preferences, ultimately improving patient outcomes and experience. The integration of these imaging techniques holds promise for optimizing non-surgical treatments like RT and monitoring treatment progress, offering a personalized approach to NMSC management.