Physical prehabilitation improves the postoperative outcome of associating liver partition and portal vein ligation for staged hepatectomy in experimental model

Physical prehabilitation improves the postoperative outcome of associating liver partition and portal vein ligation for staged hepatectomy in experimental model

Aiming to improve the postoperative outcome of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), the effect of physical prehabilitation (PP) was investigated in experimental model. Male Wistar rats (n = 106) divided to PP and sedentary (S) groups underwent ALPPS. C...

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Veröffentlicht in:Scientific reports 2022-11, Vol.12 (1), p.19441-19441, Article 19441
Hauptverfasser: Daradics, Noemi, Levay, Klara, Horvath, Ildiko, Kovacs, Noemi, Mathe, Domokos, Szigeti, Krisztian, Szijarto, Attila, Fulop, Andras
Format: Artikel
Sprache:eng
Schlagworte:
692/4020/4021/1607/1610
692/4028/546
Animal models
Animals
Computed tomography
Endotoxemia
Hepatectomy
Hepatectomy - methods
Humanities and Social Sciences
Humans
Ki-67 Antigen
Laboratories
Ligation
Liver
Liver - surgery
Liver Neoplasms
Liver Regeneration
Magnetic resonance imaging
Male
Models, Theoretical
Mortality
multidisciplinary
Portal vein
Portal Vein - surgery
Postoperative period
Preoperative Exercise
Rats
Rats, Wistar
Science
Science (multidisciplinary)
Scintigraphy
Single photon emission computed tomography
Treatment Outcome
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Zusammenfassung:Aiming to improve the postoperative outcome of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), the effect of physical prehabilitation (PP) was investigated in experimental model. Male Wistar rats (n = 106) divided to PP and sedentary (S) groups underwent ALPPS. Changes in liver weight, Ki67 index and liver volume by magnetic resonance imaging (MRI) were evaluated. Liver function was assessed by laboratory parameters and 99m Tc-mebrofenin single-photon emission computed tomography (SPECT) hepatobiliary scintigraphy (HBS). Utilizing endotoxemia model mortality and septic parameters were investigated. Liver mass ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-23744-2