Branched-Chain Amino Acid (BCAA) Oligopeptide Determination from Whey Proteins: Preparation, Peptide Profiles, and Anti-Fatigue Activity

Whey proteins have anti-fatigue activity, but there are few studies that have reported the ameliorative effects of branched-chain amino acid (BCAA) oligopeptides from whey proteins on fatigue in mice. The purposes of this study were to establish a process for the preparation of BCAA oligopeptides fr...

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Veröffentlicht in:	Foods 2024-12, Vol.14 (1), p.32
Hauptverfasser:	Zhu, Qiong, Zhou, Renjie, Zhu, Xiping, Lu, Xiangru, Ai, Binli, Zhuang, Qibin, Cui, Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids anti-fatigue activity Biotechnology branched-chain amino acid (BCAA) Chain branching Chemical synthesis Chronic fatigue syndrome Ethanol Fatigue High performance liquid chromatography Liquid chromatography Mass spectrometry Mass spectroscopy Oligopeptides Pentapeptides Peptides Proteins Serotonin serotonin (5-hydroxytryptamine, 5-HT) Swimming Trypsin Tryptophan Whey Whey protein
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Zusammenfassung:	Whey proteins have anti-fatigue activity, but there are few studies that have reported the ameliorative effects of branched-chain amino acid (BCAA) oligopeptides from whey proteins on fatigue in mice. The purposes of this study were to establish a process for the preparation of BCAA oligopeptides from whey protein and to investigate the anti-fatigue activity of BCAA oligopeptides. Whey proteins were hydrolyzed by trypsin and flavourzyme and purified by ethanol precipitation and reversed-phase high performance liquid chromatography (RP-HPLC). Fraction D' was found to contain the highest content of BCAAs and a high proportion of low-molecular-weight peptides (
ISSN:	2304-8158 2304-8158
DOI:	10.3390/foods14010032