Registered report: the CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

The Willingham et al., 2012, published in PNAS in 2012. The key experiments being replicated are those reported in Figure 6A-C and Table S4. In these experiments, Willingham et al., 2012 test the safety and efficacy of anti-CD47 antibody treatment in immune competent mice utilizing a syngeneic model...

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Veröffentlicht in:	eLife 2015-01, Vol.4, p.6662
Hauptverfasser:	Chroscinski, Denise, Maherali, Nimet, Griner, Erin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - metabolism Breast cancer Cancer Cancer therapies CD47 CD47 Antigen - metabolism Cell culture Cell Line, Tumor Cloning Communication Experiments Female Hematology Human Biology and Medicine Humans Laboratories Leukemia Lymphoma Mammary gland methodology Mice Molecular Targeted Therapy Multiple myeloma Neoplasms - drug therapy Neoplasms - metabolism Protein Binding Proteins Receptors, Immunologic - metabolism Registered Report Reproducibility Reproducibility Project: Cancer Biology Software Solid tumors targeted therapy Therapeutic applications Tumors
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The Willingham et al., 2012, published in PNAS in 2012. The key experiments being replicated are those reported in Figure 6A-C and Table S4. In these experiments, Willingham et al., 2012 test the safety and efficacy of anti-CD47 antibody treatment in immune competent mice utilizing a syngeneic model of mammary tumor growth in FVB mice. The Reproducibility Project: Cancer Biology is a collaboration between the eLife.
ISSN:	2050-084X 2050-084X
DOI:	10.7554/eLife.04586