Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome

We have determined the complete nucleotide and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002. This constitutes the first complete genetic characteriza...

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Veröffentlicht in:	Memórias do Instituto Oswaldo Cruz 2006-05, Vol.101 (3), p.307-313
Hauptverfasser:	Miagostovich, Marize Pereira, dos Santos, Flávia Barreto, Fumian, Túlio Machado, Guimarães, Flávia Ramos, da Costa, Eliane Veiga, Tavares, Fernando Neto, Coelho, Janice Oliveira, Nogueira, Rita Maria Ribeiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Base Sequence Brazil complete genome Dengue Virus - genetics Dengue Virus - isolation & purification Dengue virus type 3 dengue virus type 3 - complete genome - Brazil Fatal Outcome Female Genotype Humans PARASITOLOGY Phylogeny RNA, Viral - genetics Severe Dengue - virology TROPICAL MEDICINE
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Beschreibung
Zusammenfassung:	We have determined the complete nucleotide and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002. This constitutes the first complete genetic characterization of a Brazilian DENV-3 strain since its introduction into the country in 2001. DENV-3 was responsible for the most severe dengue epidemic in the state, based on the highest number of reported cases and on the severity of clinical manifestations and deaths reported.
ISSN:	1678-8060 0074-0276 0074-0276 1678-8060
DOI:	10.1590/S0074-02762006000300015