Expression profile of LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia

Expression profile of LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia

Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Several studies demonstrated the role of lncRNAs and miRNAs in the pathogenesis of preeclampsia; the aim was to detect the expression profiles of serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in pati...

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Veröffentlicht in:Non-coding RNA research 2023-12, Vol.8 (4), p.481-486
Hauptverfasser: Ayoub, Shymaa E., Shaker, Olfat G., Aboshama, Rehab Abdelhamid, Etman, Mohamed K., Khalefa, Abeer A., khamiss Abd elguaad, Mohamed M., Zaki, Othman M., Ali, Doaa Y., Hemeda, Nada F., Amin, Amal, Ali, Marwa A.
Format: Artikel
Sprache:eng
Schlagworte:
LncRNA ANRIL
miR-181a
miR-186
MTMR-3
Original
Preeclampsia
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Zusammenfassung:Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Several studies demonstrated the role of lncRNAs and miRNAs in the pathogenesis of preeclampsia; the aim was to detect the expression profiles of serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia. The study included 160 subjects divided into 80 subjects considered as a control group, 80 patients with preeclampsia. We found that there was a significant difference between the preeclampsia and control groups with up-regulation of miR-186 median (IQR) = 4, 29 (1.35–7.73) (P 
ISSN:2468-0540
2468-0540
DOI:10.1016/j.ncrna.2023.06.001