Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma

We report a new 131 I-labeling functional platform for targeted single-photon emission computed tomography (SPECT) imaging and radiotherapy of breast adenocarcinoma. In this study, polyethyleneimine (PEI) based nanogels (P.NH 2 NGs) were prepared by water/oil polymerization, modified with targeted a...

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Veröffentlicht in:Frontiers in bioengineering and biotechnology 2022-07, Vol.10, p.973141
Hauptverfasser: Kong, Lingdan, Zhu, Jingyi, Su, Hongxing, Zhao, Lingzhou, Lu, Yi, Zhu, Meilin, Sun, Wenjie
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Sprache:eng
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Zusammenfassung:We report a new 131 I-labeling functional platform for targeted single-photon emission computed tomography (SPECT) imaging and radiotherapy of breast adenocarcinoma. In this study, polyethyleneimine (PEI) based nanogels (P.NH 2 NGs) were prepared by water/oil polymerization, modified with targeted agent phenylboronic acid (PBA), and labeled with radionuclide 131 I. The NGs without 131 I-labeling own a spherical structure, uniform size distribution, and good cell viability. After 131 I-labeling, the obtained 131 I-PBA-PHP NGs displayed much higher cellular uptake than the non-targeted NGs due to the good softness and fluidity of NGs and the PBA targeting. The in vivo results demonstrated that 131 I-PBA-PHP NGs could specifically target breast cancer cells and efficiently aggregate into xenograft breast adenocarcinoma for tumor SPECT imaging and specific radiotherapy. The developed 131 I-labeling NGs may be used as a promising platform for efficient radioactive theranostic nanoplatform of tumor.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.973141