Immune-related long non-coding RNA signature identified prognosis and immunotherapeutic efficiency in bladder cancer (BLCA)

Immune-related long non-coding RNA signature identified prognosis and immunotherapeutic efficiency in bladder cancer (BLCA)

As bladder cancer was recognized to be immunogenic, dozens of studies have focused on immune biology of BLCA, but little is known about its relationship with the long non-coding RNAs (lncRNAs). LASSO Cox regression model was used to establish immune-related lncRNAs signature (IRLS) in BLCA. The immu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer Cell International 2020-06, Vol.20 (1), p.276-18, Article 276
Hauptverfasser: Cao, Rui, Yuan, Lushun, Ma, Bo, Wang, Gang, Tian, Ye
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
BCG
Biomarkers
Bladder cancer
Correlation analysis
Epithelium
FDA approval
Gene expression
Genomes
Immune checkpoint
Immune infiltration
Immune response
Immunogenicity
Immunotherapy
Infiltration
LncRNA
Medical prognosis
Metastases
Non-coding RNA
Patients
Primary Research
Prognosis
Regression analysis
RNA
TCGA
Tumor microenvironment
Tumorigenesis
Tumors
Urogenital system
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:As bladder cancer was recognized to be immunogenic, dozens of studies have focused on immune biology of BLCA, but little is known about its relationship with the long non-coding RNAs (lncRNAs). LASSO Cox regression model was used to establish immune-related lncRNAs signature (IRLS) in BLCA. The immune infiltration landscape of BLCA was conducted via ssGSEA and immunotherapy response was calculated through TIDE algorithm. A total of 82 immune-related lncRNAs were screened out according to spearman correlation analysis with the immune score (|R| > 0.4, p 
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-020-01362-0