Novel substituted heteroaromatic piperazine and piperidine derivatives as inhibitors of human enterovirus 71 and coxsackievirus a16

A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackie...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2013-04, Vol.18 (5), p.5059-5071
Hauptverfasser:	Zhang, Xian, Wang, Hongliang, Li, Yuhuan, Cao, Ruiyuan, Zhong, Wu, Zheng, Zhibing, Wang, Gang, Xiao, Junhai, Li, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-CVA16 activity anti-EV71 activity Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Binding sites Capsid Proteins - antagonists & inhibitors Capsid Proteins - chemistry Capsid Proteins - metabolism Chlorocebus aethiops Crystal structure Enterovirus A, Human - chemistry Enterovirus A, Human - growth & development Enterovirus A, Human - metabolism Enterovirus Infections - drug therapy Enterovirus Infections - metabolism Epidemics Genomes Humans Infections Ligands Lipids piperazine derivative Piperazines - chemical synthesis Piperazines - chemistry Piperazines - pharmacology piperidine derivatives Piperidines - chemical synthesis Piperidines - chemistry Piperidines - pharmacology Proteins Vero Cells virtual screening Viruses
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Zusammenfassung:	A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules18055059