Treatment of recurrent pediatric myelodysplastic syndrome post hematopoietic stem cell transplantation

Treatment of recurrent pediatric myelodysplastic syndrome post hematopoietic stem cell transplantation

Key Clinical Message Treatment of recurrent myelodysplastic syndrome (MDS) after hematopoietic cell transplantation (HCT) remains challenging. We present a 4‐year‐old girl experiencing early MDS relapse post‐HCT treated with a multimodal strategy encompassing a second HCT and innovative targeted the...

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Veröffentlicht in:Clinical case reports 2023-11, Vol.11 (11), p.e8190-n/a
Hauptverfasser: Wachter, Franziska, Pikman, Yana, Bledsoe, Jacob, Kapadia, Malika, Baumeister, Susanne, Rowe, Jared, Shimamura, Akiko, Place, Andrew E., Prockop, Susan, Whangbo, Jennifer, Lehmann, Leslie, Horan, John, Pollard, Jessica
Format: Artikel
Sprache:eng
Schlagworte:
Bone marrow
Chemotherapy
Clinical trials
Cytokines
Disease control
Flow cytometry
Graft versus host disease
Granulocytes
hematopoietic stem cell transplantation
Leukemia
Lymphocytes
Mortality
Myelodysplastic syndromes
Pediatrics
relapse
Remission (Medicine)
Stem cell transplantation
Surveillance
Toxicity
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Zusammenfassung:Key Clinical Message Treatment of recurrent myelodysplastic syndrome (MDS) after hematopoietic cell transplantation (HCT) remains challenging. We present a 4‐year‐old girl experiencing early MDS relapse post‐HCT treated with a multimodal strategy encompassing a second HCT and innovative targeted therapies. We underscore the potential of a comprehensive treatment approach in managing recurrent pediatric MDS.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.8190