Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010-2011

To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respective...

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Veröffentlicht in:	Emerging infectious diseases 2013-09, Vol.19 (9), p.1511-1513
Hauptverfasser:	Smits, Saskia L, Zijlstra, Ed E, van Hellemond, Jaap J, Schapendonk, Claudia M E, Bodewes, Rogier, Schürch, Anita C, Haagmans, Bart L, Osterhaus, Albert D M E
Format:	Artikel
Sprache:	eng
Schlagworte:	Causes of Cerebrospinal fluid Cerebrospinal Fluid - virology Circoviridae - classification Circoviridae - genetics Circoviridae Infections - epidemiology Circoviridae Infections - virology cyclovirus Dispatch Expedited Gene Order Genes, Viral Genetic aspects Genome, Viral Health aspects Humans Identification and classification Malawi Metagenomics Molecular Sequence Data Paraplegia Phylogeny Prevalence random amplification serum Viral genetics virus Viruses
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Beschreibung
Zusammenfassung:	To identify unknown human viruses, we analyzed serum and cerebrospinal fluid samples from patients with unexplained paraplegia from Malawi by using viral metagenomics. A novel cyclovirus species was identified and subsequently found in 15% and 10% of serum and cerebrospinal fluid samples, respectively. These data expand our knowledge of cyclovirus diversity and tropism.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1909.130404