Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations

Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations

We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagn...

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Veröffentlicht in:Case reports in hematology 2019-01, Vol.2019 (2019), p.1-4
Hauptverfasser: Cicconi, Laura, Lo-Coco, Francesco, Ottone, Tiziana, Lavorgna, Serena, De Bellis, Eleonora, Palmieri, R., Meconi, F., Mariotti, Benedetta, Martini, Vincenza
Format: Artikel
Sprache:eng
Schlagworte:
Blood
Bone marrow
Case Report
Case reports
Chromosomes
Cloning
Dasatinib
Hematology
Kinases
Leukemia
Lymphoma
Mutation
Nervous system
Patients
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Beschreibung
Zusammenfassung:We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.
ISSN:2090-6560
2090-6579
DOI:10.1155/2019/6707506