HLA in isolated REM sleep behavior disorder and Lewy body dementia

Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:0...

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Veröffentlicht in:	Annals of clinical and translational neurology 2023-09, Vol.10 (9), p.1682-1687
Hauptverfasser:	Yu, Eric, Krohn, Lynne, Ruskey, Jennifer A, Asayesh, Farnaz, Spiegelman, Dan, Shah, Zalak, Chia, Ruth, Arnulf, Isabelle, Hu, Michele T M, Montplaisir, Jacques Y, Gagnon, Jean-François, Desautels, Alex, Dauvilliers, Yves, Gigli, Gian Luigi, Valente, Mariarosaria, Janes, Francesco, Bernardini, Andrea, Högl, Birgit, Stefani, Ambra, Ibrahim, Abubaker, Heidbreder, Anna, Sonka, Karel, Dusek, Petr, Kemlink, David, Oertel, Wolfgang, Janzen, Annette, Plazzi, Giuseppe, Antelmi, Elena, Figorilli, Michela, Puligheddu, Monica, Mollenhauer, Brit, Trenkwalder, Claudia, Sixel-Döring, Friederike, Cochen De Cock, Valérie, Ferini-Strambi, Luigi, Dijkstra, Femke, Viaene, Mineke, Abril, Beatriz, Boeve, Bradley F, Rouleau, Guy A, Postuma, Ronald B, Scholz, Sonja W, Gan-Or, Ziv
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antigens Behavior disorders Brief Communication Brief Communications Consortia Dementia Genomes Haplotypes HLA Antigens HLA-DRB1 Chains Human health and pathology Humans Immune system Lewy Body Disease Life Sciences Parkinson's disease Quality control REM Sleep Behavior Disorder Sleep Statistical power Synucleinopathies
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Zusammenfassung:	Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (p = 0.00102) and 70 (p = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.
ISSN:	2328-9503 2328-9503
DOI:	10.1002/acn3.51841