Synthesis and biological evaluation of aryl 1,2,4-oxadiazole incorporated (2-(oxazol)-1H-imidazoles as anticancer agents

A new series of 1,2,4-oxadiazole incorporated (2-(oxazol)-1H-imidazole derivatives 9a-j have been developed and synthesized. Further, the newly prepared compounds (9a-j)compounds were evaluated for their preliminary anticancer properties against four human cancer cell lines like prostate cancer (PC3&DU-145), lung cancer (A549), and breast cancer (MCF-7) by using of MTT method and etoposide used as a positive reference. The obtained results indicated that most of the tested compounds displayed excellent to moderate activity. Among all derivatives, six compounds 9a, 9b, 9c, 9d, 9e, and 9f exhibited more potent anticancer activity than etoposide.