Sequence Analysis of Toxin Gene-Bearing Corynebacterium diphtheriae Strains, Australia

Sequence Analysis of Toxin Gene-Bearing Corynebacterium diphtheriae Strains, Australia

By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria. These findings highlight the importance of extrapharyngeal infections for toxin gene-bearing...

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Veröffentlicht in:Emerging infectious diseases 2017-01, Vol.23 (1), p.105-107
Hauptverfasser: Doyle, Christine J, Mazins, Adam, Graham, Rikki M A, Fang, Ning-Xia, Smith, Helen V, Jennison, Amy V
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Australia - epidemiology
bacterial infections
Bacterial proteins
Corynebacterium diphtheriae
Corynebacterium diphtheriae - genetics
Corynebacterium diphtheriae - pathogenicity
Corynebacterium infections
Diphtheria
Diphtheria - epidemiology
Diphtheria - immunology
Diphtheria - microbiology
Diphtheria - prevention & control
diphtheria toxin
Diphtheria Toxin - biosynthesis
Diphtheria Toxin - genetics
Diphtheria Toxoid - administration & dosage
Dispatch
Epidemiological Monitoring
Genes
Genes, Bacterial
Genetic research
Health aspects
Humans
Lower Extremity - microbiology
Lower Extremity - pathology
Mass Vaccination
Medical research
Mutation
Pharynx - microbiology
Pharynx - pathology
Sequence Analysis of Toxin Gene–Bearing
Skin
Skin - microbiology
Skin - pathology
Strains, Australia
Travelers
Vaccines
wound infection
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Beschreibung
Zusammenfassung:By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria. These findings highlight the importance of extrapharyngeal infections for toxin gene-bearing (functional or not) and non-toxin gene-bearing C. diphtheriae strains. Continued surveillance is recommended.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2301.160584