PPARγ and Cognitive Performance

PPARγ and Cognitive Performance

Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For the...

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Veröffentlicht in:International journal of molecular sciences 2019-10, Vol.20 (20), p.5068
Hauptverfasser: d'Angelo, Michele, Castelli, Vanessa, Catanesi, Mariano, Antonosante, Andrea, Dominguez-Benot, Reyes, Ippoliti, Rodolfo, Benedetti, Elisabetta, Cimini, Annamaria
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Animal cognition
Animals
autism
Autistic Disorder - genetics
Autistic Disorder - metabolism
Axonogenesis
Brain-derived neurotrophic factor
Cognition
Cognition Disorders - genetics
Cognition Disorders - metabolism
Cognitive ability
Glucose
Humans
huntington
Kinases
Ligands
Localization
Memory
Mitochondria
Neuroprotection
Neuroprotective agents
Nuclear receptors
Parkinson Disease - genetics
Parkinson Disease - metabolism
Parkinson's disease
Pathology
Phosphorylation
ppar gamma
PPAR gamma - genetics
PPAR gamma - metabolism
pparγ agonists
Proteins
Review
schizophrenia
Schizophrenia - genetics
Schizophrenia - metabolism
Synaptic plasticity
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Beschreibung
Zusammenfassung:Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For these reasons, many PPARγ ligands have been proposed for the improvement of cognitive performance in different pathological conditions. In this review, the research on this issue is extensively discussed.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20205068