Anti-Inflammatory Cembrane-Type Diterpenoids and Prostaglandins from Soft Coral Lobophytum sarcophytoides

Two new cembrane-type diterpenoids, lobophytins A ( ) and B ( ), and four new prostaglandins, (5 )-PGB ( ), (5 )-13,14-dihydro-PGB ( ), 13,14-dihydro-PGB ( ) and 13,14-dihydro-PGB -Me ( ), together with ten known compounds were isolated from the soft coral . The structures of these new secondary met...

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Veröffentlicht in:	Marine drugs 2019-08, Vol.17 (8), p.481
Hauptverfasser:	Shen, Hongjie, Liu, Xiaowan, Jiang, Minghua, Luo, Guangyuan, Wu, Zhenger, Chen, Bin, Li, Jing, Liu, Lan, Chen, Senhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthozoa - chemistry anti-inflammatory Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Cell Line cembrane-type diterpenoid Circular dichroism Corals Dichroism Diterpenes Diterpenes - pharmacology Fatty acids Indomethacin Inflammation Lipopolysaccharides Lipopolysaccharides - pharmacology Lobophytum Magnetic Resonance Spectroscopy - methods Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Metabolites Mice Nitric oxide Nitric Oxide - metabolism NMR Nuclear magnetic resonance prostaglandin Prostaglandins Prostaglandins - pharmacology RAW 264.7 Cells Secondary metabolites soft coral Spectrum analysis
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Zusammenfassung:	Two new cembrane-type diterpenoids, lobophytins A ( ) and B ( ), and four new prostaglandins, (5 )-PGB ( ), (5 )-13,14-dihydro-PGB ( ), 13,14-dihydro-PGB ( ) and 13,14-dihydro-PGB -Me ( ), together with ten known compounds were isolated from the soft coral . The structures of these new secondary metabolites were identified by high resolution mass spectrometry (HR-ESIMS), nuclear magnetic resonance (NMR) and electron circular dichroism (ECD) analyses, as well as the modified Mosher's method. Compounds , , , , , , and showed potential anti-inflammatory activity by inhibiting the production of nitric oxide (NO) in RAW264.7 cells that were activated by lipopolysaccharide, with IC values ranging from 7.1 to 32.1 μM and were better than the positive control indomethacin, IC = 39.8 μM.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md17080481