Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development

Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development

The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen express...

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Veröffentlicht in:Pathogens (Basel) 2023-01, Vol.12 (1), p.138
Hauptverfasser: Schmidt, Christin, Schnierle, Barbara S
Format: Artikel
Sprache:eng
Schlagworte:
alphavirus
Antigens
Cancer
Chromatography
Coronaviruses
COVID-19
COVID-19 infection
COVID-19 vaccines
DNA methylation
Efficiency
Gene expression
Immune response
Immune system
Infectious diseases
Innate immunity
Kinases
Lipids
mRNA
mRNA vaccines
Pandemics
Pathogens
Review
RNA
RNA polymerase
self-amplifying RNA
vaccine
Vaccine development
Vaccines
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Zusammenfassung:The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens12010138