New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

Three previously undescribed iridoids, cornusfurals A⁻C, were isolated from the ethanolic extracts of fruits of . Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2019-02, Vol.24 (3), p.625
Hauptverfasser: Ji, Lin-Lin, Wang, Xin, Li, Jin-Jie, Zhong, Xiang-Jian, Zhang, Bo, Juan, Jing, Shang, Xiao-Ya
Format: Artikel
Sprache:eng
Schlagworte:
Chromatography
Cornus officinalis
Corticosterone
Ethanol
Fruits
Infrared spectroscopy
iridoid
Mass spectrometry
Mass spectroscopy
Neuroprotection
neuroprotective activity
NMR
Nuclear magnetic resonance
Pheochromocytoma cells
Ultraviolet spectroscopy
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Beschreibung
Zusammenfassung:Three previously undescribed iridoids, cornusfurals A⁻C, were isolated from the ethanolic extracts of fruits of . Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24030625