COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis

Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and surveillance of immunocompromised patients at...

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Veröffentlicht in:Frontiers in immunology 2020-08, Vol.11, p.2086
Hauptverfasser: Schramm, Markus A, Venhoff, Nils, Wagner, Dirk, Thiel, Jens, Huzly, Daniela, Craig-Mueller, Nils, Panning, Marcus, Hengel, Hartmut, Kern, Winfried V, Voll, Reinhard E
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Sprache:eng
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Zusammenfassung:Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and surveillance of immunocompromised patients at high risk for severe disease progression. With only few case studies published on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide, and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA).
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.02086