Antioxidant, Anti-Diabetic, Anti-Obesity, and Antihypertensive Properties of Protein Hydrolysate and Peptide Fractions from Black Sesame Cake

A low-value by-product of cold-pressed sesame oil is defatted black sesame cake (DBSC). The remaining protein and essential amino acids may be utilized as a renewable biological source to produce bioactive products. The bioactivities of the protein hydrolysate from black sesame cake and its peptide...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.28 (1), p.211
Hauptverfasser:	Chaipoot, Supakit, Punfa, Wanisa, Ounjaijean, Sakaewan, Phongphisutthinant, Rewat, Kulprachakarn, Kanokwan, Parklak, Wason, Phaworn, Laddawan, Rotphet, Pattrawan, Boonyapranai, Kongsak
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amylases alpha-Glucosidases - chemistry Amino acids Amylases Antidiabetics Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology Antihypertensives Antioxidants Antioxidants - chemistry Biological activity Diabetes Diabetes Mellitus Diet therapy enzymatic hydrolysis Enzymes Ferric ions Food quality Free radicals Functional foods Functional foods & nutraceuticals Glucosidase Hydrolysates Hyperglycemia Hypertension in vitro study membrane filtration Molecular weight Obesity peptide Peptides Peptides - chemistry Polypeptides Protein hydrolysates Protein Hydrolysates - chemistry Protein Hydrolysates - pharmacology Proteins Redox reactions Seeds sesame Sesame oil Sesamum Sesamum - metabolism Type 2 diabetes Ultrafiltration α-Amylase α-Glucosidase
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Zusammenfassung:	A low-value by-product of cold-pressed sesame oil is defatted black sesame cake (DBSC). The remaining protein and essential amino acids may be utilized as a renewable biological source to produce bioactive products. The bioactivities of the protein hydrolysate from black sesame cake and its peptide fractions were examined in this study for in vitro antioxidant activity and inhibition of DPP-IV, ACE, α-amylase, α-glucosidase, and pancreatic lipase. By using Flavourzyme to hydrolyze DBSC, followed by ultrafiltration, fractions with peptide sizes of 10 kDa were obtained. According to the findings, the products of DBSC could neutralize free radicals and prevent ferric ion redox reactions. The highest inhibitory effects were shown with low Mw peptides (
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules28010211