Clinical and Immunological Profile of Anti-factor H Antibody Associated Atypical Hemolytic Uremic Syndrome: A Nationwide Database

Clinical and Immunological Profile of Anti-factor H Antibody Associated Atypical Hemolytic Uremic Syndrome: A Nationwide Database

Atypical hemolytic uremic syndrome (aHUS), an important cause of acute kidney injury (AKI), is characterized by dysregulation of the alternative complement pathway. Autoantibodies to factor H (FH), a chief regulator of this pathway, account for a distinct subgroup. While high anti-FH titers predict...

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Veröffentlicht in:Frontiers in immunology 2019-06, Vol.10, p.1282-1282
Hauptverfasser: Puraswani, Mamta, Khandelwal, Priyanka, Saini, Himanshi, Saini, Savita, Gurjar, Bahadur Singh, Sinha, Aditi, Shende, Rajashri Pramod, Maiti, Tushar Kanti, Singh, Abhishek Kumar, Kanga, Uma, Ali, Uma, Agarwal, Indira, Anand, Kanav, Prasad, Narayan, Rajendran, Padmaraj, Sinha, Rajiv, Vasudevan, Anil, Saxena, Anita, Agarwal, Sanjay, Hari, Pankaj, Sahu, Arvind, Rath, Satyajit, Bagga, Arvind
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
atypical hemolytic uremic syndrome
Atypical Hemolytic Uremic Syndrome - immunology
Atypical Hemolytic Uremic Syndrome - pathology
Atypical Hemolytic Uremic Syndrome - therapy
Autoantibodies - immunology
Autoantigens - immunology
Child
Child, Preschool
Complement Factor H - immunology
Databases, Factual
factor H
Female
Humans
Immunology
Immunosuppressive Agents - therapeutic use
Infant
Male
plasma exchange
renal reserve
thrombotic microangiopathy
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Zusammenfassung:Atypical hemolytic uremic syndrome (aHUS), an important cause of acute kidney injury (AKI), is characterized by dysregulation of the alternative complement pathway. Autoantibodies to factor H (FH), a chief regulator of this pathway, account for a distinct subgroup. While high anti-FH titers predict relapse, they do not correlate well with disease activity and their functional characterization is required. Of 781 patients
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.01282