Effects of praziquantel on common carp embryos and larvae

This study aimed to assess the toxicity of praziquantel (anthelmintic drug) in different developmental stages of common carp ( Cyprinus carpio ) based on mortality, early ontogeny, growth, oxidative stress, antioxidant enzymes, histology and behaviour. Praziquantel at all tested concentrations rangi...

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Veröffentlicht in:	Scientific reports 2022-10, Vol.12 (1), p.17290-9, Article 17290
Hauptverfasser:	Velisek, Josef, Zuskova, Eliska, Kubec, Jan, Sandova, Marie, Stara, Alzbeta
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 692/700 704/172 Animals Antioxidants - pharmacology Antiparasitic agents Aquaculture Carp Carps Catalase Catalase - pharmacology Chemical oxygen demand Cyprinus carpio Developmental stages Drug dosages Embryo, Nonmammalian Embryos Ethanol Fish Fisheries Histology Humanities and Social Sciences Laboratory animals Larva Larvae Mortality multidisciplinary Ontogeny Oxidative stress Parasites Praziquantel Praziquantel - pharmacology Science Science (multidisciplinary) Superoxide dismutase Superoxide Dismutase - pharmacology Toxicity Water Pollutants, Chemical - toxicity
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Beschreibung
Zusammenfassung:	This study aimed to assess the toxicity of praziquantel (anthelmintic drug) in different developmental stages of common carp ( Cyprinus carpio ) based on mortality, early ontogeny, growth, oxidative stress, antioxidant enzymes, histology and behaviour. Praziquantel at all tested concentrations ranging from 1 to 4 mg/L showed no significant adverse effects on mortality, the early ontogeny and behaviour locomotory (activity, moved distance and velocity) of carp after 35-day exposure. Concentrations of 3 and 4 mg/L caused significantly ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-21679-2