Effect of minor amounts of β-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of β-tricalcium phosphate cylinders

Effect of minor amounts of β-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of β-tricalcium phosphate cylinders

β-Tricalcium Phosphate (β-TCP), one of the most used bone graft substitutes, may contain up to 5 wt% foreign phase according to standards. Typical foreign phases include β-calcium pyrophosphate (β-CPP) and hydroxyapatite (HA). Currently, the effect of small amounts of impurities on β-TCP resorption...

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Veröffentlicht in:Bioactive materials 2022-04, Vol.10, p.222-235
Hauptverfasser: Le Gars Santoni, B., Niggli, L., Dolder, S., Loeffel, O., Sblendorio, G.A., Heuberger, R., Maazouz, Y., Stähli, C., Döbelin, N., Bowen, P., Hofstetter, W., Bohner, M.
Format: Artikel
Sprache:eng
Schlagworte:
Bioceramics
Calcium phosphate
Hydroxyapatite
Osteoclastic resorption
β‐Calcium pyrophosphate
β‐Tricalcium phosphate
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Zusammenfassung:β-Tricalcium Phosphate (β-TCP), one of the most used bone graft substitutes, may contain up to 5 wt% foreign phase according to standards. Typical foreign phases include β-calcium pyrophosphate (β-CPP) and hydroxyapatite (HA). Currently, the effect of small amounts of impurities on β-TCP resorption is unknown. This is surprising since pyrophosphate is a very potent osteoclast inhibitor. The main aim of this study was to assess the effect of small β-CPP fractions (
ISSN:2452-199X
2452-199X
DOI:10.1016/j.bioactmat.2021.09.003