Hypoxia and the Tumor Microenvironment

Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lea...

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Veröffentlicht in:	Technology in Cancer Research & Treatment 2021, Vol.20, p.15330338211036304-15330338211036304
Hauptverfasser:	Li, Yue, Zhao, Long, Li, Xiao-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Cell Proliferation Glycolysis Humans Hypoxia Immune response Metastases Neoplasms - physiopathology Neoplasms - therapy Neovascularization, Pathologic Signal Transduction Targeting Diagnosis and Treatment in Cancer Tumor Escape Tumor Hypoxia - physiology Tumor microenvironment Tumor Microenvironment - physiology Tumors
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Beschreibung
Zusammenfassung:	Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.
ISSN:	1533-0346 1533-0338
DOI:	10.1177/15330338211036304