Effects of IMOD ™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats

Diabetes is associated with vascular complications and impaired angiogenesis. Since angiogenesis plays a crucial role in vascular homeostasis in ischemic heart diseases, in this study, the effect of IMOD™ on and expression level which are altered in impaired angiogenesis were investigated in heart tissue of diabetic rats. Forty male Wistar rats (200-250 g) were randomly classified into 4 groups: control (C), IMOD™ (I), diabetes (D), and diabetes+IMOD™ (D+I). For induction of experimental diabetes in animals, a single dose of streptozotocin (STZ; 60mg/kg) was injected intraperitoneally. After 8 weeks of treatment with IMOD™ (20 mg/kg/day), heart tissue samples were removed and used for measurement of and expression level as well as histological studies. Results of this study showed that diabetes decreased heart tissue angiogenesis which was associated with increased and reduced expression levels (p