Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma

Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clinic of Clinical Center Banja Luka, from January 1st 1997 till January 1st 1999. Statistical data analysis was performed and correlation of prognostic factors was determined. The majority of authors in this field agree that the primary tumor size and axillary nodal status are the two most important prognostic factors. These factors are the best predictors of prognosis and survival of women who had the tumor and were operated on. Tumor markers were immunohistochemically determined in the last ten years and, according to the majority of authors, are still considered the additional or relative prognostic factors in breast carcinoma. Their prognostic value and significance increase almost daily. Most frequently determined tumor markers are bcl-2, pS2, Ki-67 and p53. There was a positive, directly proportional relationship between primary tumor size and tumor suppressor gene p53, but there was no positive correlation between the axillary nodal status and tumor suppressor gene p53. Significance of determination of new tumor markers as the prognostic factors was emphasized. These markers represent a powerful tool in the early detection and prevention of breast carcinoma. Analizovana je povezanost standardnih patomorfoloskih prognostickih parametara, velicine primarnog tumora i aksilarnog nodusnog statusa sa novim faktorom prognoze kod karcinoma dojke tumor supresornim genom p53 Analizovani uzorak obuhvata 65 zena operisanih zbog karcinoma dojke na Hirurskoj klinici Klinickog centra, Banja Luka u periodu od 1. januara 1997 do 1. januara 1999. godine. Izvrsena je statisticka obrada podataka i utvrdjena povezanost ispitivanih prognostickih faktora. Vecina autora u svijetu, koja se bavi problemom karcinoma dojke, slaze se da su velicina primarnog tumora i aksilarni nodusni status dva najvaznija prognosticka faktora. Ovi faktori najbolje govore o tome kakva je prognoza i prezivljavanje zena koje su oboljele i operisane od karcinoma dojke. Tumorski markeri se odredjuju imunohistohemijski poslednjih desetak godina i, prema vecini autora, jos uvijek se smatraju dodatnim ili relativnim faktorima prognoze kod karcinoma dojke. Ipak, njihova se prognosticka vrijednost i znacaj svakog