Aggregation in the spotlight

Aggregation in the spotlight

New findings clarify apparently conflicting results about how molecular agents that preserve protein integrity prevent harmful, dense aggregates from forming.

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Veröffentlicht in:eLife 2021-10, Vol.10
Hauptverfasser: Wang, Zihao, Collier, Miranda, Benesch, Justin
Format: Artikel
Sprache:eng
Schlagworte:
aging
Amyotrophic lateral sclerosis
Biochemistry and Chemical Biology
Chaperones
FUS
Heat shock proteins
Insight
molecular condensates
Mutation
Phase transitions
Proteins
RRM
time-resolved quantitative XL-MS
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Beschreibung
Zusammenfassung:New findings clarify apparently conflicting results about how molecular agents that preserve protein integrity prevent harmful, dense aggregates from forming.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.73586