Primary cilium and glioblastoma

Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell. There is increasing evidence that abnormal cilia are in...

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Veröffentlicht in:Therapeutic Advances in Medical Oncology 2018-01, Vol.10, p.1758835918801169-1758835918801169
Hauptverfasser: Álvarez-Satta, María, Matheu, Ander
Format: Artikel
Sprache:eng
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Zusammenfassung:Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell. There is increasing evidence that abnormal cilia are involved in cancer progression, since primary cilia regulate cell cycle and signalling transduction. In this review, we summarize the role of primary cilium specifically with regard to GBM, where there is evidence postulating it as a critical mediator of GBM tumorigenesis and progression. This opens the way to the application of cilia-targeted therapies (‘ciliotherapy’) as a new approach in the fight against this devastating tumour.
ISSN:1758-8340
1758-8359
1758-8359
DOI:10.1177/1758835918801169