Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer

Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species (ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis. Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase...

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Veröffentlicht in:	Antioxidants 2022-12, Vol.12 (1), p.67
Hauptverfasser:	Akhiani, Ali A, Martner, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Angiogenesis Biochemistry & Molecular Biology Cancer Cell growth cell-proliferation class-ia pi3k dependent activation Enzymes Food Science Infectious Medicine Infektionsmedicin Inflammation inhibitor Kinases Malignancy metastasis NAD(P)H oxidase nadph oxidase NOX Oxidation Oxidative stress p47(phox) pathway Pharmacology & Pharmacy Phosphatase phosphorylation PI3K pathway Prostate Proteins Reactive oxygen species Regulation respiratory burst Review Signal transduction T cell receptors Technology Thyroid gland Tumorigenesis
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Zusammenfassung:	Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species (ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis. Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in several malignancies. In this review, we examine the role of PI3K on the regulation of NOX-induced ROS formation in cancer.
ISSN:	2076-3921 2076-3921
DOI:	10.3390/antiox12010067