Platelet activation and red blood cell changes in thrombotic and rheological disturbances among coronary heart disease patients

Aim. To assess the role of platelet (PL) and red blood cell (RBC) function changes in RBC-PL aggregate (RPA) formation among coronary heart disease (CHD) patients. Material and methods. The study included 22 CHD patients (mean age 57±7 years) and 14 healthy volunteers (mean age 48±3 years). PL and R...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Kardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika 2007-10, Vol.6 (5), p.18-24
Hauptverfasser:	T. E. Shirokova, L. I. Buryachkovskaya, A. B. Sumarokov, I. A. Uchitel, E. G. Popov, A. V. Vavaev
Format:	Artikel
Sprache:	rus
Schlagworte:	coronary heart disease hemorheology mean platelet volume platelet activation and aggregation red blood cell aggregation and resistance red blood cell and platelet aggregates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Aim. To assess the role of platelet (PL) and red blood cell (RBC) function changes in RBC-PL aggregate (RPA) formation among coronary heart disease (CHD) patients. Material and methods. The study included 22 CHD patients (mean age 57±7 years) and 14 healthy volunteers (mean age 48±3 years). PL and RBC aggregation, RBC resistance were assessed with laser aggregation analyzer BIOLA. Circulating RPA counting and their morphological assessment were performed by scanning electromicroscopy. Mean PL volume (MPLV) was assessed by thrombocrit measurement. Results. In CHD patients, spontaneous PL aggregation was higher than in controls (1,6±0,4 vs 1,1±0,3 U; p
ISSN:	1728-8800 2619-0125