Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects

Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy. This review aims to...

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Veröffentlicht in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2022-09, Vol.15 (9), p.1145
Hauptverfasser: Ramli, Fitri Fareez, Hashim, Syed Alhafiz Syed, Raman, Betty, Mahmod, Masliza, Kamisah, Yusof
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Sprache:eng
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Zusammenfassung:Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy. This review aims to present the updated development of the roles of trientine in hypertrophic cardiomyopathy. The drug has been demonstrated in animal studies to restore myocardial intracellular copper content. However, its mechanisms for improving the medical condition remain unclear. Thus, comprehending its mechanistic aspects in cardiomyopathy is crucial and could help to expedite future research.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph15091145