Vitamin D Deficiency and Its Association with Iron Deficiency in African Children

Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism. Although vitamin D and iron deficiency are highly prevalent globally, little is known about their interactions in Africa. To evaluate associations between vitamin D and iron status we measured markers...

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Veröffentlicht in:	Nutrients 2022-03, Vol.14 (7), p.1372
Hauptverfasser:	Mogire, Reagan M, Muriuki, John Muthii, Morovat, Alireza, Mentzer, Alexander J, Webb, Emily L, Kimita, Wandia, Ndungu, Francis M, Macharia, Alex W, Cutland, Clare L, Sirima, Sodiomon B, Diarra, Amidou, Tiono, Alfred B, Lule, Swaib A, Madhi, Shabir A, Prentice, Andrew M, Bejon, Philip, Pettifor, John M, Elliott, Alison M, Adeyemo, Adebowale, Williams, Thomas N, Atkinson, Sarah H
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Age Anemia Biomarkers Calciferol Child Children Ferritin Hemoglobin Hepcidin Humans Inflammation Inflammation - epidemiology Iron Iron Deficiencies iron deficiency Laboratories Malaria Markers Meta-analysis Metabolism Nutrient deficiency Nutrient status Parasitemia Prevalence Quality control Regression analysis South Africa Vaccines Vector-borne diseases Vitamin D Vitamin D deficiency Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology Vitamin deficiency Vitamins
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Zusammenfassung:	Vitamin D regulates the master iron hormone hepcidin, and iron in turn alters vitamin D metabolism. Although vitamin D and iron deficiency are highly prevalent globally, little is known about their interactions in Africa. To evaluate associations between vitamin D and iron status we measured markers of iron status, inflammation, malaria parasitemia, and 25-hydroxyvitamin D (25(OH)D) concentrations in 4509 children aged 0.3 months to 8 years living in Kenya, Uganda, Burkina Faso, The Gambia, and South Africa. Prevalence of iron deficiency was 35.1%, and prevalence of vitamin D deficiency was 0.6% and 7.8% as defined by 25(OH)D concentrations of
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu14071372