Sequential gastroenteritis episodes caused by 2 norovirus genotypes

We investigated sequential episodes of acute norovirus gastroenteritis in a young child within an 11-month period. The infections were caused by 2 distinct genotypes (GII.4 and GII.6). Failure to achieve cross-protective immunity was linked to absence of an enduring and cross-reactive mucosal immune...

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Veröffentlicht in:	Emerging infectious diseases 2014-06, Vol.20 (6), p.1016-1018
Hauptverfasser:	Parra, Gabriel I, Green, Kim Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral - blood Caliciviridae Infections - diagnosis Caliciviridae Infections - immunology Caliciviridae Infections - virology Child, Preschool diarrhea Dispatch Feces - virology Female Gastroenteritis Gastroenteritis - diagnosis Gastroenteritis - immunology Gastroenteritis - virology Genetic aspects Genotype Health aspects Humans immunity Immunity, Mucosal Immunoglobulin A - blood Infant Norovirus Norovirus - classification Norovirus - genetics Norovirus - immunology Norovirus - isolation & purification Phylogeny RNA, Viral - genetics Viral Structural Proteins - genetics viruses
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Zusammenfassung:	We investigated sequential episodes of acute norovirus gastroenteritis in a young child within an 11-month period. The infections were caused by 2 distinct genotypes (GII.4 and GII.6). Failure to achieve cross-protective immunity was linked to absence of an enduring and cross-reactive mucosal immune response, a critical consideration for vaccine design.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2006.131627