Rare complication of hepatocellular carcinoma in Wilson's disease

The complication of hepatocellular carcinoma (HCC) in Wilson's disease is rare. Wilson's disease treatment using D‐penicillamine (DPA) is useful to prevent HCC occurrence; however, it also causes iron accumulation and synergistic radical formation in the liver, which may enhance carcinogenesis. Reported herein is a case of HCC in Wilson's disease treated with DPA for 36 years. The tumor was surgically resected and histologically diagnosed with moderately differentiated HCC surrounded by cirrhotic tissue with fatty infiltration. Rhodanine staining revealed a slight positively stained area in both tumor and surrounding tissues. Information obtained from this case and literature review highlight the feature of HCC in Wilson's disease. A complication of the hepatocellular carcinoma (HCC) in Wilson's disease is rare. The treatment for Wilson's disease using D‐penicillamine is useful to prevent HCC occurrence; however, it also causes iron accumulation and synergistic radical formation in the liver which may enhance the carcinogenesis. We report a case of HCC in Wilson's disease treated with D‐penicillamine for 36 years.