Quantitative [99mTc]Tc-MDP SPECT/CT correlated with [18F]NaF PET/CT for bone metastases in patients with prostate cancer

Background The purpose of the present study was to elucidate the correlation between standardized uptake value (SUV) and volume-based parameters measured by quantitative [ 99m Tc]Tc-methylene diphosphonate (MDP) single photon emission computed tomography (SPECT)/CT and [ 18 F]-sodium fluoride ([ 18 F]NaF) positron emission tomography (PET)/CT in the assessment of bone metastases in patients with prostate cancer. Methods The study included 26 male prostate cancer patients with confirmed or suspected bone metastases who underwent both [ 99m Tc]Tc-MDP SPECT/CT and [ 18 F]NaF PET/CT studies. Skeletal lesions visible on both SPECT/CT and PET/CT were classified as benign or metastases. The maximum SUV (SUVmax), peak SUV (SUVpeak), mean SUV (SUVmean), metabolic bone volume (MBV), and total bone uptake (TBU) were calculated for every lesion showing abnormal uptake. Results A total of 202 skeletal lesions (147 benign and 55 metastases) were detected in the 26 patients. Strong significant correlations were noted between SPECT/CT and PET/CT for the SUV- and volume-based parameters (all P