Podocyte Density and Albuminuria in Aging Diabetic Ins2± Mice with or Without Adenosine A1 Receptor Signaling

To investigate podocyte density in aging diabetic Ins2± and Ins2±, A1AR-/- mouse models in C57Bl/6 background. Ins2± mice and especially Ins2±, adenosine A1 receptor knockout mice (Ins2±, A1AR-/-) are mouse models with a phenotype of diabetic nephropathy. Aged mice (at ~40 weeks) were assessed for g...

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Veröffentlicht in:	International journal of nephrology and renovascular disease 2020-02, Vol.13, p.19-26
Hauptverfasser:	Faulhaber-Walter, Robert, Jiang, Lanping, Mizel, Diane, Zerfas, Patricia M, Kopp, Jeffrey B, Schnermann, Jurgen B, Chen, Limeng, Schiffer, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Age Aging Animal models Comparative analysis Diabetes Diabetes mellitus diabetes nephropathy podocyte mouse akita wt-1 Diabetic nephropathies Diabetic nephropathy Drinking water EDTA Electron microscopy Filtration Genotype & phenotype Glomerulus Glucose Histology House mouse Kidney diseases Kidneys Laboratory animals Metabolism Microscopy Nephroblastoma Nephropathy Original Research Phenotypes Proteins Rodents Tumors Type 2 diabetes Urine
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Zusammenfassung:	To investigate podocyte density in aging diabetic Ins2± and Ins2±, A1AR-/- mouse models in C57Bl/6 background. Ins2± mice and especially Ins2±, adenosine A1 receptor knockout mice (Ins2±, A1AR-/-) are mouse models with a phenotype of diabetic nephropathy. Aged mice (at ~40 weeks) were assessed for glomerular filtration barrier function by measuring albuminuria, glomerular filtration, glomerular damage by electron microscopy, and podocyte numbers by Wilms Tumor protein (WT-1) staining. Compared to healthy wild-type mice, both diabetic mouse models developed diabetic nephropathy, including hyperfiltration (p
ISSN:	1178-7058 1178-7058
DOI:	10.2147/IJNRD.S203810