Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats

Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats

Glucocorticoid excess adversely affects male reproduction. This study evaluates effects of pharmacological doses of niacin on testicular structure and function in dexamethasone‐treated rats. Adult rats (48) were randomly assigned to 6 equal groups: (1) Negative control (NC): normal rats; (2) Positiv...

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Veröffentlicht in:Pharmacology Research & Perspectives 2023-10, Vol.11 (5), p.e01128-e01128
Hauptverfasser: Azimi Zangabad, E., Shomali, Tahoora, Roshangar, L.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apoptosis
Dexamethasone
Drug dosages
Enzymes
glucocorticoid
Ketamine
Motility
Niacin
Original
Pharmacology
rats
Sample size
Sperm
Spermatogenesis
testes
Testosterone
Variance analysis
Vitamin B
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Beschreibung
Zusammenfassung:Glucocorticoid excess adversely affects male reproduction. This study evaluates effects of pharmacological doses of niacin on testicular structure and function in dexamethasone‐treated rats. Adult rats (48) were randomly assigned to 6 equal groups: (1) Negative control (NC): normal rats; (2) Positive control (PC): dexamethasone at 7 mg/kg/day by intraperitoneal injections for 7 days; groups 3–6 (N50, N100, N200, and N400): dexamethasone and concomitant treatment with niacin at 50, 100, 200, and 400 mg/kg/day by oral gavages. Testicular weight and volume of PC rats were significantly lower than the NC group ( p  
ISSN:2052-1707
2052-1707
DOI:10.1002/prp2.1128