Cerebrospinal Fluid MicroRNA Changes in Cognitively Normal Veterans With a History of Deployment-Associated Mild Traumatic Brain Injury

Cerebrospinal Fluid MicroRNA Changes in Cognitively Normal Veterans With a History of Deployment-Associated Mild Traumatic Brain Injury

A history of traumatic brain injury (TBI) increases the odds of developing Alzheimer's disease (AD). The long latent period between injury and dementia makes it difficult to study molecular changes initiated by TBI that may increase the risk of developing AD. MicroRNA (miRNA) levels are altered...

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Veröffentlicht in:Frontiers in neuroscience 2021-09, Vol.15, p.720778-720778
Hauptverfasser: Lusardi, Theresa A, Sandau, Ursula S, Sakhanenko, Nikita A, Baker, Sarah Catherine B, Wiedrick, Jack T, Lapidus, Jodi A, Raskind, Murray A, Li, Ge, Peskind, Elaine R, Galas, David J, Quinn, Joseph F, Saugstad, Julie A
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer’s disease
cerebrospinal fluid
deployment
microRNA
mild traumatic brain injury
Neuroscience
veterans
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Zusammenfassung:A history of traumatic brain injury (TBI) increases the odds of developing Alzheimer's disease (AD). The long latent period between injury and dementia makes it difficult to study molecular changes initiated by TBI that may increase the risk of developing AD. MicroRNA (miRNA) levels are altered in TBI at acute times post-injury (
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2021.720778