Predominance of rotavirus P[4]G2 in a vaccinated population, Brazil

We identified 21 rotaviruses in 129 patients with diarrhea in a Brazilian city with high rotavirus vaccine coverage. All rotaviruses were genotype P[4]G2 with 1 mixed infection with P[NT]G9. Although virus predominance could have occurred randomly, the vaccine may be less protective against P[4]G2....

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Veröffentlicht in:	Emerging infectious diseases 2007-10, Vol.13 (10), p.1571-1573
Hauptverfasser:	Gurgel, Ricardo Q, Cuevas, Luis E, Vieira, Sarah C F, Barros, Vanessa C F, Fontes, Paula B, Salustino, Eduardo F, Nakagomi, Osamu, Nakagomi, Toyoko, Dove, Winifred, Cunliffe, Nigel, Hart, Charles A
Format:	Artikel
Sprache:	eng
Schlagworte:	Brazil Brazil - epidemiology Child Child, Preschool Cohort Studies diarrhea Dispatch Dysentery - immunology Dysentery - virology Genotype genotypes Health aspects Humans Infant Infection Mass Vaccination Rotavirus Rotavirus - classification Rotavirus - genetics Rotavirus Infections - epidemiology Rotavirus Infections - immunology Rotavirus Infections - virology Rotavirus Vaccines - immunology Vaccination vaccine Vaccines, Attenuated - immunology
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Zusammenfassung:	We identified 21 rotaviruses in 129 patients with diarrhea in a Brazilian city with high rotavirus vaccine coverage. All rotaviruses were genotype P[4]G2 with 1 mixed infection with P[NT]G9. Although virus predominance could have occurred randomly, the vaccine may be less protective against P[4]G2. Prospective surveillance is urgently needed.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1310.070412