The mir-21 Inhibition Enhanced HUVEC Cellular Viability during Hypoxia-Reoxygenation Injury by Regulating PDCD4

The mir-21 Inhibition Enhanced HUVEC Cellular Viability during Hypoxia-Reoxygenation Injury by Regulating PDCD4

The purpose of this study was to explore the clinical value of altered plasma mir-21 expression level as a biomarker for the severity of coronary artery disease (CAD) and its molecular impact on HUVEC cellular injuries. Angiographically validated 56 patients with single-vessel CAD disease, 92 patien...

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Veröffentlicht in:Mediators of inflammation 2022-06, Vol.2022, p.1-10
1. Verfasser: Ali Sheikh, Md Sayed
Format: Artikel
Sprache:eng
Schlagworte:
Acute coronary syndromes
Aging
Apoptosis
Biomarkers
Cardiac patients
Cardiology
Cardiovascular disease
Caspase-3
Cell viability
Coronary artery
Coronary heart disease
Coronary vessels
Cytokines
Ethylenediaminetetraacetic acid
Gene expression
Geriatrics
Heart diseases
Hospitals
Hypoxia
MicroRNAs
Patients
Stenosis
Tumor necrosis factor-TNF
Vein & artery diseases
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Zusammenfassung:The purpose of this study was to explore the clinical value of altered plasma mir-21 expression level as a biomarker for the severity of coronary artery disease (CAD) and its molecular impact on HUVEC cellular injuries. Angiographically validated 56 patients with single-vessel CAD disease, 92 patients with double-vessel CAD, 139 complex coronary artery stenosis patients, and 56 healthy individuals (n=343) were enrolled in this study. The expressions of plasma mir-21 were evidently and progressively higher while PDCD4 levels were significantly and steadily lower in single-, dual-, and multivessel occluded CAD patients than in healthy participants (P
ISSN:0962-9351
1466-1861
DOI:10.1155/2022/9661940