Emblica officinalis mitigates intestinal toxicity of mice by modulating gut microbiota in lead exposure

Lead (Pb) contamination has been affecting public health for decades. As a plant-derived medicine, the safety and effectiveness of Emblica officinalis (E. officinalis) fruit extract has been emphasized. The current study focused on mitigating the adverse effects of lead (Pb) exposure in reducing its...

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Veröffentlicht in:	Ecotoxicology and environmental safety 2023-03, Vol.253, p.114648-114648, Article 114648
Hauptverfasser:	Wang, Yaping, Zhou, Hui, Che, Yanyun, Wan, Xin, Ding, Xiaoxue, Zheng, Shengnan, Wu, Chenyang, Qin, Miao, Xu, Yanling, Yu, Yi, Kulyar, Muhammad Fakhar-e-Alam, Li, Kun, Wu, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood serum colon cytokines dose response ecotoxicology Emblica officinalis exposure models fruit extracts Gastrointestinal Microbiome Gut barrier Gut microbiota histopathology homeostasis inflammation intestinal microorganisms Intestinal Mucosa - metabolism Intestinal toxicity Intestines - pathology Lead Lead - metabolism medicine Mice Mice, Inbred C57BL occludins Phyllanthus emblica public health species tight junctions toxicity weight loss
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Zusammenfassung:	Lead (Pb) contamination has been affecting public health for decades. As a plant-derived medicine, the safety and effectiveness of Emblica officinalis (E. officinalis) fruit extract has been emphasized. The current study focused on mitigating the adverse effects of lead (Pb) exposure in reducing its toxicity worldwide. According to our findings, E. officinalis significantly improved weight loss and colon length shortening (p
ISSN:	0147-6513 1090-2414
DOI:	10.1016/j.ecoenv.2023.114648