Macrophage Polarity and Disease Control

Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages and M2 macrophages, which are altered by various factors such as microorganisms, tissue microenvironment, and cytokine signals. Macrophage pola...

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Veröffentlicht in:	International journal of molecular sciences 2021-12, Vol.23 (1), p.144
Hauptverfasser:	Kadomoto, Suguru, Izumi, Kouji, Mizokami, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autoimmune diseases Bacteria Bone marrow Cell Polarity - physiology cell-cell interaction Cytokines Cytokines - metabolism Disease Disease control Genotype & phenotype HIV Homeostasis Human immunodeficiency virus Human tissues Humans Infections Infectious diseases Inflammatory diseases Lungs Macrophages Macrophages - metabolism Macrophages - pathology microenvironment Microenvironments Microorganisms monocytes Nitric oxide Phenotypes Polarity Review Therapeutic targets Tuberculosis Tumor necrosis factor-TNF
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Beschreibung
Zusammenfassung:	Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages and M2 macrophages, which are altered by various factors such as microorganisms, tissue microenvironment, and cytokine signals. Macrophage polarity is very important for infections, inflammatory diseases, and malignancies; its management can be key in the prevention and treatment of diseases. In this review, we assess the current state of knowledge on macrophage polarity and report on its prospects as a therapeutic target.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms23010144