Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study

Although primaquine (PQ) is indicated for G6PD-deficient patients, data on weekly PQ use in Brazil are limited. We aimed to investigate malaria recurrences among participants receiving daily and weekly PQ treatments in a real-life setting of two municipalities in the Amazon between 2019 and 2020. Pa...

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Veröffentlicht in:	Revista da Sociedade Brasileira de Medicina Tropical 2022-01, Vol.55, p.e07382021-e07382021
Hauptverfasser:	Brito-Sousa, Jose Diego, Phanor, Jeffe, Balieiro, Patricia Carvalho da Silva, Silva-Neto, Alexandre Vilhena, Cordeiro, Jady Shayenne Mota, Vitor-Silva, Sheila, Mendes, Maxwell, Sampaio, Vanderson Souza, Melo, Gisely Cardoso de, Lacerda, Marcus, Monteiro, Wuelton
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - therapeutic use Brazilian Amazon Cohort Studies Elimination G6PD deficiency Humans Malaria, Vivax - drug therapy Primaquine - therapeutic use Recurrence Recurrences Short Communication TROPICAL MEDICINE Weekly primaquine
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Zusammenfassung:	Although primaquine (PQ) is indicated for G6PD-deficient patients, data on weekly PQ use in Brazil are limited. We aimed to investigate malaria recurrences among participants receiving daily and weekly PQ treatments in a real-life setting of two municipalities in the Amazon between 2019 and 2020. Patients receiving weekly PQ treatment had a lower risk of recurrence than those receiving daily PQ treatment (risk ratio: 0.62, 95% confidence interval: 0.41-0.94), using a model adjusted for study site. Weekly PQ use did not increase the risk of malaria recurrence. Further studies with larger populations are warranted.
ISSN:	0037-8682 1678-9849 1678-9849
DOI:	10.1590/0037-8682-0738-2021