Radiation-induced arterial ischemia from the treatment of Gorham-Stout disease

Chronic radiation arterial injury is generally predictable by known tumor types and anatomic location. Radiation-associated peripheral arterial occlusion secondary to the management of rare Gorham-Stout Disease (GSD), “Vanishing Bone Disease”, has rarely, if ever, been described. A patient with GSD, previously treated with shoulder and scapular reconstruction, radiation therapy, and delayed endovascular stent placement in the axillary artery presented with acute right upper extremity ischemia from recurrent radiation induced arterial stenosis. The patient underwent a successful staged revision revascularization procedure. This case highlights a rare condition where patients may be at high risk for radiation-induced arterial injury with the potential need for revascularization.